The incidence of acute kidney injury in children undergoing allogenic hematopoietic stem cell transplantation: A pilot study

Background Acute kidney injury (AKI) is a common feature in adults undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). However, accurate assessment of AKI incidence the pediatric population still seems challenge. Objectives To evaluate according to pRIFLE criteria children alloHSCT, with special focus on differences between patients transplanted due oncological and non-oncological indications. Material methods A retrospective analysis data, concerning 135 alloHSCT (89 patients) or other (46 reasons, was performed. The values estimated glomerular filtration rate (eGFR) were measured before 24 h after, 1, 2, 3, 4, 8 weeks, 3 6 months after analyzed. Results diagnosed 54% all patients. Risk stage (R) noticed at least once 46% 37% children. Injury (I) concerned 12% 6% alloHSCT. both groups comparable. mean eGFR higher than those even until 4th week increased significantly returned pre-transplantation records 2-3 weeks. Then, demonstrated gradual decrement eGFR. Six transplantation, lower compared records, whereas children, these Conclusions Although type indication for has no impact incidence, reasons are greater risk renal impairment